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整合微型電磁致動器之聚合酶連鎖反應晶片
A Self-contained Miniaturized PCR System


賈婷婷、楊勝安、鄭茗元、林俊良、林啟萬 教授、楊燿州 教授


     The development of a portable polymerase chain reaction (PCR) device is presented.  The fully integrated self-contained system consists of four major parts: a disposable chamber chip with micro-channels and pumping membranes, a heater chip with micro-heaters and temperature sensors, a linear array of electromagnetic actuators, and a control/sensing circuit.  The system can be fully operated with a 5V DC voltage, and does not require any external air compressor or bulky power supply.  The size of the whole system is 67mm × 66mm × 25mm, and is smaller than a PDA cell-phone.  The miniaturized PCR system not only has the advantage of smaller size, less consumption of DNA solution, but also can effectively reduce the PCR process time into one-third of the time required by typical commercial PCR system.



        
研究著作:
B T. Chia, S.-A. Yang, M.-Y. Cheng, C.-L. Lin, C.-W. Lin and Y.-J. Yang, “A Self-contained Miniaturized PCR System,” IEEE MEMS 2009, Sorrento, Italy, Jan. 25-29, 2009.
 

  電磁驅動式聚合酶連鎖反應微晶片系統
A Self-contained Miniaturized PCR System Using Electromagnetic Actuators

賈婷婷  楊勝安  鄭茗元  林俊良

發表於 IEEE MEMS Conference 2009, Sorrento, Italy.


聚合酶連鎖反應(PCR)為生醫領域中體外擴增基因片段的重要技術,常見應用於DNA定序、醫療診斷、疾病檢測等。

透過微機電技術(micro-electro-mechanical system, MEMS)製作的微流道晶片(microfluidic chip)與微加熱器晶片(micro heater chip),再加上控制電路(control/sensing module)與流體驅動元件(electromagnetic actuator)所組成之PCR微系統體積比PDA手機還小,僅需接上電源即可使用,可減少反應時間、減少DNA使用量,成功取代了大型實驗操作機台。

 

 



 

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